Lovastatin 20 mg Side Effects
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Is Lovastatin black box warning?
Uses ; Lovastatin is used together with a proper diet to lower cholesterol and triglyceride (fat) levels in the blood. This medicine may also help prevent medical problems (eg, chest pain, heart attack, stroke) caused by fat clogging the blood vessels.
Important warnings ;;
- Serious muscle damage warning : Using lovastatin raises your risk of serious muscle problems. These problems include myopathy, with symptoms that include muscle pain, tenderness, or weakness. Myopathy can lead to rhabdomyolysis. With this condition, muscle breaks down and can cause kidney damage and even death. If you have unexplained muscle pain or weakness, stop taking lovastatin right away and call your doctor.
- Liver disease warning : Use of lovastatin raises your risk of liver disease. Your doctor should check how well your liver is working before and during treatment with this drug. Drinking alcohol can increase your risk of liver problems from lovastatin. If you drink alcohol, talk to your doctor before starting this medication.
Lovastatin side effects ;
Lovastatin oral tablet doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
* Common side effects that can occur with use of lovastatin include:
- pain in your stomach area,
- nausea,
- heartburn,
- constipation,
- headache,
- weakness/lack of energy,
- muscle pain,
- memory loss/forgetfulness,
- confusion,
- inability to fall asleep,
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
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* Serious side effects and their symptoms can include the following:
;; Muscle problems. Symptoms can include unexplained:
- muscle pain
- muscle tenderness
- muscle weakness
;; Liver problems. Symptoms can include:
- dark-colored urine
- yellowing of your skin or whites of your eyes
;; Stomach problems. Symptoms can include:
- pain in the upper right part of your stomach area
- nausea
- loss of appetite
;; Central nervous system problems. Symptoms can include:
- lack of energy
- weakness
- extreme tiredness
;; Skin problems. Symptoms can include:
- rash
- hives
- itching
;; Bleeding problems. Symptoms can include:
- unusual bleeding or bruising
;; Flu-like symptoms. Symptoms can include :
- fever,
- body aches,
- tiredness,
- cough,
- Hoarseness,
* Lovastatin may interact with other medications;
Lovastatin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
Examples of drugs that can cause interactions with lovastatin are listed below.
;; Antibiotics;
Taking certain antibiotics with lovastatin can cause high levels of lovastatin to build up in your body. This raises your risk of side effects from lovastatin, including serious muscle pain, weakness, and breakdown. These drugs should not be used with lovastatin.
Examples of these drugs include:
- clarithromycin,
- erythromycin,
- Antifungal drugs,
Taking certain antifungal drugs with lovastatin can cause high levels of lovastatin to build up in your body. This raises your risk of side effects from lovastatin, including serious muscle pain, weakness, and breakdown. These drugs should not be used with lovastatin.
Examples of these drugs include:
- itraconazole,
- voriconazole,
- ketoconazole,
- posaconazole,
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HIV drugs;
Taking certain HIV drugs with lovastatin can cause high levels of lovastatin to build up in your body. This raises your risk of side effects from lovastatin, including serious muscle pain, weakness, and breakdown. These drugs should not be used with lovastatin.
Examples of these drugs include :
protease inhibitors such as:
- ritonavir,
- nelfinavir,
- medications that contain cobicistat,
Blood thinner;
Warfarin is a type of blood thinner called an anticoagulant. When warfarin and lovastatin are taken together, this can increase the effects of warfarin. This raises your risk of bleeding. Your doctor should closely monitor your INR (a blood test) if you take warfarin with lovastatin.
Cholesterol drugs;
Taking lovastatin with certain drugs used to lower cholesterol levels raises your risk of severe muscle problems. Some of these drugs should be avoided if you are taking lovastatin. Others may be used with careful monitoring. Talk to your doctor to find out if taking these drugs is safe for you.
Examples of these drugs include :
- niacin,
- gemfibrozil,
fibrates, such as :
- fenofibrate,
- fenofibric acid,
Gout drug ;
Colchicine is used to treat gout. Taking this drug with lovastatin raises your risk of serious muscle problems. These include muscle pain, weakness, and breakdown. Use this drug cautiously with lovastatin.
Heart drugs ;
Taking certain blood pressure and heart drugs with lovastatin raises your risk of serious muscle problems. These include muscle pain, weakness, and muscle breakdown. Your doctor may advise you to avoid these drug combinations. If you do take a heart drug with lovastatin, your doctor may lower your dosage of lovastatin. Examples of these heart drugs include:
- amiodarone,
- diltiazem,
- ranolazine,
- verapamil,
- dronedarone,
Hormone therapy ;
Danozol is a hormone drug used to treat conditions such as endometriosis, breast disease, or angioedema. Taking this drug with lovastatin raises the risk of severe muscle problems. These problems include muscle pain, weakness, or breakdown. Your doctor may advise you to avoid this drug combination. If you do take this drug with lovastatin, your doctor may lower your dosage of lovastatin.
Immunosuppressant drug ;
Cyclosporine is used to suppress the immune system. It may be used to treat conditions such as rheumatoid arthritis or psoriasis. It may also be used after a solid organ transplant. Taking this drug with lovastatin raises your risk of serious muscle problems. This drug should not be used with lovastatin.
Ulcer drug ;
Cimetidine is used to treat ulcers and other gastrointestinal problems. When used with lovastatin, cimetidine can decrease the amount of natural steroids in the body. This can cause side effects such as tiredness, muscle weakness, reduced sex drive, or mood problems.
This drug comes with several warnings.
Allergy warning,
Lovastatin can cause a severe allergic reaction.
Symptoms can include:
- trouble breathing or swallowing
- swelling of your face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- rash
- hives
- itching
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it.
Taking it again could be fatal (cause death).
; Food interaction warning ;
Eating grapefruit or drinking grapefruit juice can increase the level of lovastatin in your body. This raises your risk of serious muscle pain or damage. Avoid drinking grapefruit juice or eating grapefruit while taking this drug.
; Alcohol interaction warning ;
Drinking alcohol can increase your risk of liver problems from lovastatin. If you drink alcohol, tell your doctor before starting this medication.
; Warnings for people with certain health conditions ;
For people with liver disease: If you have active liver disease, you should not take lovastatin. If you have a history of liver disease, your doctor will check how well your liver is working before and during treatment with this drug. If you have unexplained increases in your liver enzymes during treatment, your doctor will likely stop your use of this drug.
For people with kidney problems: You may be at an increased risk of side effects from lovastatin. This is especially true if your creatinine clearance is less than 30 mL/min.
Warnings for other groups ;
For pregnant women:
Lovastatin should never be used during pregnancy.
It can cause harm to a fetus due to its effects on how the body processes cholesterol and other substances.
For women who are breastfeeding:
It is not known if lovastatin passes into breast milk. Other medications in this class pass into breast milk and can cause side effects in a child who is breastfed.
For seniors :
The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects from lovastatin.